Advanced stem cell therapy with Mesenchymal Stem Cells

STEM CELLS

WHAT ARE STEM CELLS?

WHERE DO STEM CELLS COME FROM?

Stem cells can be obtained from various tissues such as fatty tissue, bone marrow, umbilical cord cells, umbilical cord blood, dental pulp, among others. In cell therapy, these stem cells are expanded and cultured in the Cell Bank of BioXcellerator, obtaining a higher cellular number of high qualities, to be subsequently reintroduced into the individual through different routes, depending on the patient's medical condition.

Cells derived from adipose tissue, bone marrow, and umbilical cord have unique advantages such as ease to obtain, absence of risk of immune rejection, immediate availability, minimal risk of complications, infections and disability.

Stem cells act through the secretion of bioactive molecules. Dr. Arnold Caplan, the pioneer in the research of mesenchymal stem cells and adjudicator of his name MSC, proposed to rename these cells as medicinal signaling cells or Medicinal Signaling Cells (MSC) for its acronym in English, because the most important function of these cells they are the factors that they secrete.

THE CHARACTERISTICS AND PROPERTIES OF THE MSC (MEDICINAL SIGNALING CELLS)

• The capacity of numerous cycles of cell division to maintain the undifferentiated state or its capacity for self-renewal.
• They are found in multiple tissues of the body.
• One of its main functions is to maintain cell balance and replace cells that are becoming sick or dying (apoptosis) and under pathological conditions has the potential to regenerate damaged tissue.
• They can generate many types of specialized cells. Being multipotent can be differentiated into a subset of cell types such as bone, cartilage, adipose tissue, muscle, endothelial cells, among others.
• They synthesize and secrete a set of trophic factors (growth factors) that stimulate or activate the patient's own cells, promoting their expansion or proliferation, among other functions.
• They have the ability to migrate to affected areas through inflammatory signals released in pathological conditions (Homing).

STEM CELLS WORK WITH THE FOLLOWING MECHANISMS:

• Stimulation of cell differentiation
• Immunomodulation and inflation control: mesenchymal stem cells have strong anti-inflammatory and immunomodulatory properties. These cells regulate the immune system and reduce inflammation helping in the treatment of autoimmune and inflammatory conditions.
• Signaling: MSCs secrete a large number of cytokines, chemokines, and trophic factors, which stimulate the endogenous MSCs for differentiation, mobilization, and proliferation.

TYPES OF STEM CELLS

According to their origin:

• Adults: they are also called somatic and are those that can be extracted from any person, regardless of their age. They can be found in specific areas (MSC niches) of all tissues and parts of the body, staying dormant for long periods until they are activated either to complete the cell renewal cycle, or to repair a damaged tissue due to an illness or an injury.
• Embryonic: are those found in embryos more than four or five days old and from them develop all the tissues and organs of the fetus. Given their very high differentiation capacity, they can be transformed into any type of cell, they are the most interesting from the research perspective, but they raise important ethical questions that have led to prohibiting their use in most countries.
• Perinatal: are those that can be obtained from tissues that are normally discarded after the birth of a baby such as: placenta, umbilical cord, amniotic membrane, amniotic fluid and umbilical cord. Of the cells of the umbilical cord it is necessary to differentiate between those that can be extracted from the cord blood and those of the umbilical cord tissue that are known as Wharton's gelatin cells. The blood cells of the umbilical cord are of hematopoietic origin, therefore, there are differences between their functions and possible utilities.
• Reprogrammed or iPS: these cells are differentiated adults, which are forced to re-express genes associated with embryonic stages, therefore, they return to express characteristics of embryonic stem cells without the ethical conflicts of these cells. Their disadvantage is that they are genetically modified so they can be unstable.

According to the patient:

• Autologous: They are characteristic of the same individual.

• Allogenic: Of different individuals of the same species

• Xenogenic: From a different species differentiation

According to their potential:

• Totipotent: They have the capacity to form a complete organism. They are not used in cellular therapies.
• Pluripotent: They have the potential to develop any type of cell. They are obtained from the blastocyst or by cell reprogramming. They are not used in cellular therapies due to ethical conflicts and genetic instability, respectively. Very used in research. High risk of producing tumors.
• Multipotent: They are called organ-specific or adult stem cells capable of generating any type of cell from their germ layer. They are used in cell therapy.

Types of stem cells most used

• Mesenchymal Stem Cell
  
  
• Hematopoietic Stem Cells 

STEM CELL THERAPY

It is a process by which new cells are introduced to the body to treat a disease. Cell therapy involves a wide variety of cell types with regenerative, reparative, protective, or immunoregulatory characteristics, among which are the so-called stem cells or Stem Cells.

Unlike many traditional treatments, some of the high cost, with side effects, which are not directed to the causes but to the symptoms, cell therapy has had very promising and even potentially curable answers. Other countries around the world are already using cell therapy with effective results and research is increasingly hopeful and accurate, however, few clinics have legally approved therapies.

The most commonly used stem cells are the mesenchymal stem cells of Wharton's gelatin from the umbilical cord, bone marrow or stromal, and adipose tissue. For the type of condition or disease to be treated, the medical team should have a broad knowledge of the patient's condition, treatment alternatives and evidence that the steps to follow can offer a successful outcome.

WHY GET A MSC TREATMENT?

In a natural way, our body has the capacity to repair injuries that diminish as we get older. The quantity and quality of MSC that we all have also decrease with time.

The treatment with MSC consists of supplying the patient with as many cells as possible, thus increasing the body's capacity to protect, replace or regenerate damaged or diseased cells.

ADVANTAGES:

• It has few possibilities to generate rejection by the organism.
• It is an alternative treatment for medical conditions such as degenerative diseases, which do not have effective traditional pharmacological therapies.
• MSCs offer treatments with an important possibility of recovery and improvement of hope and quality of life.
• They can reverse or slow the progression of the disease.
• The MSCs of adipose tissue and bone marrow are obtained through ambulatory and low-risk processes, with local anesthesia.
• The Wharton Jelly MSCs of the umbilical cord are available at all times in the incubators of the BioXcellerator cell bank, avoiding the patient having to go through some surgical procedure for its extraction.
• They can be used for rejuvenation or anti-aging treatments.

HOW IS THE MEDICAL PROCESS OF THE TREATMENT?

STAGES OF THE TREATMENT WITH MSC

The treatment with MSC is a process that demands advanced technical and technological capacities, and a professional team highly specialized in cellular therapy. Before cell therapy, the BioXcellerator team performs the following procedures to have the cells ready at all times for our patients:

1. Obtaining umbilical cords
2. Extensive safety and quality tests on umbilical cord samples
3. Separation or isolation: the procedure by which they separate the MSCs of the tissue
4. Cultivation or expansion: the cells are cultivated in order to increase their number and their purity for the necessary dose in each pathology.
5. Cryopreservation: after expansion, the cells are stored at temperatures of -180oC for conservation and use in future doses, if necessary.

At the time of cell therapy the following steps are followed:

1. Patient evaluation, medical history, diagnostic aids
2. Patient preparation with Bioregulatory Systems Medicine, Functional Medicine, Orthomolecular Medicine, and Hyperbaric Medicine.
3. Treatment with cell therapy: Application intravenously, intramuscularly, intraarticularly, intralesionally, intrathecally, intranasally, intradermally, intradiscally, among others according to the needs of the patient.
4. Close and constant monitoring. (1, 3, 6, and 12 months)

How are therapies with stem cells enhanced?

BioXgel

The majority of therapies in BioXcellerator are complemented with BioXgel (concentration of growth factors) which are responsible for providing nutrients to the cells used and accelerating the natural process of repair, desinflammation and regeneration of tissues.

Bioxgel is obtained from a small amount of blood from the same patient, which is processed with high-quality standards which allow having a concentration of these factors.

• Hyperbaric oxygen therapy.
• Oral medications, bioregulators of systems
• IV nutrition, IV Therapy.
• Nutritional recommendations
• Recommendations for post-treatment cellular stimulation.

WHAT ARE THE REQUIREMENTS?